William
H. Brooks, M.D.
EDUCATION
Pre-Med
University of Kentucky, 1965
M.D.
University of Kentucky, 1969
INTERNSHIP AND RESIDENCY
Intern, Surgery
1969 - 1970
New York University/Bellevue
New York, New York
Resident, Neurosurgery
1970 - 1971
University of Kentucky Medical Center
Lexington, Kentucky
Elective Residency, Neuropathology/Immunology
1971 - 1972
University of Virginia
Charlottesville, Virginia
Resident, Neurosurgery
1972 - 1974
University of Kentucky Medical Center
Lexington, Kentucky
APPOINTMENTS
Chief, Neurosurgery
Veterans Administration Hospital
Lexington, Kentucky
1974 - 1978
Assistant Professor
University of Kentucky Medical Center
Division of Neurosurgery
Lexington, Kentucky
1974 - 1978
Clinical Associate Professor
University of Kentucky Medical Center
Division of Neurosurgery/Experimental Pathology
Lexington, Kentucky
1978 - Present
HOSPITAL STAFF APPOINTMENTS
Central Baptist Hospital
Lexington, Kentucky
Samaritan Hospital
Lexington, Kentucky
Saint Joseph Hospital
Lexington, Kentucky
Saint Joseph Hospital, East
Lexington, Kentucky
Kentucky Commision for Children with Special Health Care Needs
Louisville, Kentucky
Southeastern Kentucky Baptist Hospital
Corbin, Kentucky
MEDICAL SOCIETY MEMBERSHIPS
American Association of Neurological Surgeons
Congress of Neurological Surgeons
American Academy of Neurological & Orthopaedic Surgeons
American Medical Association
American Medical Equestrian Association
Fayette County Medical Society
Kentucky Medical Association
AWARDS AND HONORS
Fellowship - American Cancer Society, 1973 - 1974
Recipient of Resident's Award from Southern Neurosurgical Society
for paper entitled, Immune Responses in Patients with Gliomas, 1974
Teacher Investigator Award, 1978, NINCDS - not activated
PUBLICATIONS
Wheeler, D.D., Boyarsky, L.L.,
Brooks, W.H.: The Release of Amino Acids from Nerve During
Stimulation. Journal of Cell Physiology 67:141, 1966.
Brooks, W.H., Netsky, M.G., Horwitz, D.A.: Tumor
Specific Immune Response in Patients with Primary Brain Tumors. Surgery Forum
23, 1972.
Brooks, W.H.: Georgraphic Clustering of Brain Tumors
in Kentucky. Cancer 30:4, 1972.
Brooks, W.H., Netsky, M.G., Horwitz, D.A., Normansell, D.E.: Cell-mediated Immunity in Patients with Primary Brain Tumors.
Journal of Exp. Medicine 136:1631-1647, 1972.
Motara, R.H., Parker, J., Brooks, W.H.: Glioblastoma
Multiforme of the Spinal Cord. Surgery Neurology 2:115-119, 1974.
Mortara, R.H., Markesbery, W.,
Brooks, W.H.: Pontine Cyst Presenting as Trigeminal Pain.
Journal of Neurosurgery 41:636-639, 1974.
Brooks, W.H., Mortara, R.H., Preston, D.: Clinical
Limitation of Brain Scanning in Metastatic Disease. Journal of Nuclear
Medicine 15:620-621, 1974.
Brooks, W.H., Caldwell, H., Mortara, R.H.: Immune
Response in Patients with Gliomas. Surgical Neurology 2:419-423, 1974.
Brooks, W.H., Netsky, M.G., Levine, J.E.: Immunity and
Tumors of Central Nervous System. Surgical Neurology 3:184-186, 1975.
McCloskey, J.J., Parker, J.C., Brooks, W.H., Blacker, H.M.: Melanin as a Component of Cerebral Gliomas - the Melanotic Cerebral
Ependyoma. American Journal of Clinical Pathology 63-759, May 1975.
Young, A.B., Brooks, W.H., Blacker,
H.M., Mortara, R.H.: Microvascular Surgery for Stroke
Prevention. JAMA 73-599-601, 1975.
Mortara, R.H., Sides, S., Brooks, W.H.: Removal of an
Intracranial Glioblastoma in a Hemophiliac. Surgical Neurology 4:505-507,
December 1975.
Markesbery, W., Brooks, W.H., Milsow L., Mortara, R.H.: Ultrastructural
Study of the Pineal Germinoma in Vivo and in Vitro. Cancer 37:327-337, January
1976.
Swick, H., Brooks, W.H., Roszman, T.L., Caldwell, H.D.: A
Heath Stable Blocking Factor in Patients with Subacute Sclerosing Panencephalitis. Neurology
26:84-88, January 1976.
Brooks, W.H., Roszman, T.L., Rogers, A.S.: Impairment
of Rosette Forming T Lymphocytes in Patients Intracranial Tumors. Cancer
37:1869-1973, April 1976.
Mortara, R.H., Brooks, W.H.: Pantopaque Arachnoiditis
in the Posterior Fossa; a Case Report. Southern Medical Journal 69:52, 1976.
Brooks, W.H., Parker, J.C., Young,
A.B., Mortara, R.H.: Malignant Gliomas of the Optic Chiasm in
Adolescents. Clinical Pediatrics 15:557-561, June 1976.
Brooks, W.H., Young, A.B.: High School Football
Injuries. Prevention of Central Nervous System Injury. Southern Medical
Journal 69:1258-1260, October 1976.
Roszman, T.L., Brooks, W.H., Muse,
K.N.: Effects of Preincubating Human Peripheral Blood
Lymphocytes on their Ability to Bind Sheep Red Blood Cells. Journal Immunology
Methods 14:93-100, January 1977.
Mahaley, M.S., Brooks, W.H., Roszman, T.L., Bigner, D.D., Dudka, L., Richardson,
S.: Immunobiology of Primary Intracranial Tumors. Studies of the
Cellular and Humoral Genral Immune Competence of Brain Tumor Patients. Journal
of Neurosurgery 46:476-546, April 1977.
Brooks, W.H., Mee, J.C., Schimke, R.N.: Gonadal
Dysgenesis with Graves' Disease. Journal of Med-Genet. 14(2): 128-129, April,
1977.
Brooks, W.H., Roszman, T.L., Mahaley, M.S., Woosley, R: Immunobiology
of Primary Intracranial Tumors,. II. Analysis of Lymphocyte Subpopulations in Patients
with Primary Brain Tumors. Clinical Exp. Immunology 26:61-66, July, 1977.
Woosley, R.E., Mahaley, J.L., Miller, G.M., Brooks, W.H.: Immunobiology
of Primary Intracranial Tumors. III. Microcytotoxicity Assays of Specific Immune Responses
of Brain Tumor Patients. Journal of Neurosurgery 47:871-885, December, 1977.
Rozman, T.L., Brooks, W.H.,
Markesbery, W.R., Bigner, D.D.: General Immunocompetence of Rats
Bearing Avian Saroma Virus Induced Intracranial Tumors. Cancer Research
38:74-77, January, 1978.
Brooks, W.H., Markesbery, W.R., Gupta, G.D., Roszman, T.L.: Relationship of Lymphocyte Invasion and Survival of Brain Tumor
Patients. Annals of Neurology 4:219, 1978.
Young, A. B., Tibbs, P.A., Brooks, W.H.: Anterior
Interbody Fusion for Unstable Thoracolumbar Fractures. In Press - Journal of
Neurosurgery.
Markesbery, W.R., Brooks, W.H., Gupta, G.D., Young, A.B.: Selection
of Treatment for Patients with Cerebral Metatases. Archives of Neurology
35:754-756, 1978.
Tibbs, P.A., Young, B., McAllister, R.G., Brooks, W.H., Tackett, L.: Studies of Experimental Cervical Spinal Cord Transection. Part I. -
Hemodynamic Changes After Acute Cervical Spinal Cord Transection. Journal of
Neurosurgery 49:558-562, 1978.
Tibbs, P.A., Brooks, W.H.: Traumatic Bitemporal
Hemianopsia. In Press - Journal of Trauma.
Sims, W.L., Marx, M.B., Brooks, W.H.:
A Follow-up Study of the Geographic Distribution of Selected
Malignancies Among Kentucky Residents, 1969-1976. Journal of National Medical
Association 71(71): 685, July, 1979.
Young, B., Rapp, R., Brooks, W.H., Madauss, W., Norton, J.A.: Post-Traumatic Epilepsy Prophylaxis. Epilepsia 20:
671-681, 1979.
Roszman, T.L., Brooks, W.H.: Immunobiology of Primary
Intracranial Tumors. III. Qualitative Lymphocyte Defect in Patients with Brain Tumors.
Clinical Exp. Immunology 39:395-402, 1980.
Brooks, W.H., Mahaley, J.S., Sheline, G.E.: Adjunctive
Therapy for Malignant Primary Brain Tumors. Clinical Exp. Immunology
39:395-402, 1980.
Walker, M.D., Green, S.B., Byar, D.P., Alexander, E., Batzdorf, V., Brooks,
W.H., Hunt, W.E., MacCarty, C.S., Mahaley, M.S., Mealey, J., Owens, G., Ransohoff, J.,
Robertson, J.T., Sharpiro, W.R., Smith, K.R., Wilson, C.B., Strike, T.A.: Randomized Comparisons of Radiotherapy and Nitrosureas for the
Treatment of Malignant Glioma After Surgery. New England Journal of Medicine
303:1323-1329, 1980
Cross, R. J., Markesbery, W.R.,
Brooks, W.H., Roszman, T.L.: Hypothalamic Immune Interactions.
I. The Acute Effect of Anterior Hypothalamic Lesions on the Immune Response.
Brain Res. 196:79-87, 1980.
Brooks, W.H., Latta, R.B., Mahaley, M.D., Roszman, T.L., Dudka, L., Skaggs, C.: Immunobiology of Primary Intracranial Tumors. IV. Correction of a
Lymphocyte Index and Clinical Status. Journal of Neurosurgery 54-331-337,
1981.
Spori, M., Roszman, T.L., Brooks, W.H.: T-Lymphocyte
Heterogeneity in Rat: Role of Adherent T-cell Population in Regulating the Cytotoxic
Response. Clinical Immunology 65:103-114, 1981.
Young, B., Brooks, W.H., Tibbs, P.A.: Anterior
Decompression and Fusion for Thoracolumbar Fractures with Neurological Deficits.
Acta-Neurochir (Wien) 57(3-4): 287-298, 1981.
Roszman, T.L., Cross, R.J., Brooks, W.H., Markesbery, W.R.: Hypothalamic Immune Interactions. II. The Effect of Hypophysectomy on
Neuroimmunomodulation. Journal of Neurological Science 53:557-566, 1982.
Cross, R.J., Roszman, T.L.,
Markesbery, W.R., Brooks, W.H.: Hypothalamic Immune
Interactions. II. Effect of Hypophysectomy on Neuroimmunomodulation. Journal
of Neurological Science 53:557-566, 1982.
Brooks, W.H., Cross, R.J., Markesbery, W.R., Roszman, T.L.: Neuroimmunomodulation Neuroanatomical Basis for Impairment and
Facilitation. Ann. Neurology 12:56-61, 1982.
Roszman, T.L., Cross, R.J., Brooks, W.H., Markesbery, W.R.: Neuroimmunomodulation of Suppressor Cell Function. Immunology 45:731-742,
1982.
Markesbery, W.R., Cross, R.J., Brooks, W.H., Roszman, T.L.: Hypothalamic Immune Interactions. II. Effect of Hypophysectomy on
Neuroimmunomodulation. Journal of Neurological Sco. 53:557-566, 1982.
Roszman, T.L., Brooks, W.H., Elliott, L.H.: Immunobiology
of Primary Intracranial Tumors. VI. Suppressor Cell Function and Lectin Binding Lymphocyte
Sub-populations in Patients with Cerebral Tumors. Cancer 50:1273-1279, 1982.
Green, S.B., Byar, D.P., Walkker,
M.D., Pistenma, D.A., Alexander, E., Ulrich, B., Brooks, W.H., Hunt, W.E., Mealey, Jr.,
Odom, G.L., Pietro, P., Ransohoff, J., Robertson, J.T., Selker, R.G., Shapiro, W.R.,
Smith, K.R., Wilson, C.B., Strike, T.A.: Comparisons of
Carmustine, Procarbazine, and High-Dose Methylprednisolene as Additions to Surgery and
Radiotherapy for the Treatment of Malignant Glioma. Cancer Treatment Reports
67:121-132, 1983.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Cytokinetic
Basis for the Impaired Activation of Lympocytes from Patients with Primary Intracranial
Tumors. Journal of Immunology 132: 1208-1215, 1984.
Cross, R.J., Markesbery, W.R., Brooks, W.H., Roszman, T.L.: Hypthalamic Immune Interactions: - Neuromodulation of the Natural
Killer Activity by Lesioning of the Anterior Hypothalamus. Immunology 51:
399-11405, 1984.
Cross, R.J., Jackson, J.J., Roszman, T.L., Brooks, W.H., Markesbery, W.R.: Role of Spontaneous Interstitial Cell Testicular Tumors on the Mitogen
Reactivity of Spleen Cells from Aged Fischer 344 Rats. Mech. Aging Development
25: 349-353, 1984.
Cross, R.J., Markesbery, W.R., Brooks, W.H., Roszman, T.L.: Neuromodulation of Lymphocyte Reactivity in Aged Rats.
Neurobiology of Aging 5: 89-92, 1984.
Jackson, J.C., Cross, R.H., Walker,
R.F., Brooks, W.H., Markesbery, W.R., Roszman, T.L.: Neuroimmunomodulation:
Influence of Serotonin on the Immune Response. Immunology 54: 505-510, 1985.
Roszman, T., Jackson, J., Cross, R., Markesbery, W., Brooks, W.H.: Neuroanatomical and Neurotransmitter Influences on Immune Function. Journal
of Immunology 135: 769-772, 1985.
Cross, R.J., Jackson, J., Brooks, W.H., Sparks, D., Roszman, T., Markesbery, W.:
Neuroimmunodulation - Impairment of Humoral Immune
Responsiveness After Brain Catecholamine Depletion. In Press - Immunology.
Roszman, T.L., Brooks, W.H.: Neuromodulation of Immune
Function. Journal of Neuroimmunology 10: 59-69, 1985.
Roszman, T.L., Elliott, L.H., Steele, C., Brooks, W.H.: Pokeweed
Nitrogen Induced Immunoglobin Secretion by Peripheral Blood Lymphocyte from Patients with
Primary Brain Tumors. Journal of Immunology 134: 1545-1554, 1985.
Roszman, T.L., Cross, R.J., Brooks, W.H., Markesbery, W.R.: Neuroimmunomodulation: Effects of Neural Lesions on Cellular Immunity.
T. Melnechuk, Editor. Raven Press, New York, New York, 1985.
Roszman, T. L., Elliott, L. H.,
Steele, C., and Brooks, W.H.: Pokeweed Mitogen Induced
Immunoglobulin Secretion by Peripheral Blood Lymphocytes from Patients with Primary
Intracranial Tumors. Characterization of T-helper and B-cell Function. Journal
of Immunology 134: 1545-1554, 1985.
Jackson, J.C., Cross, R.J., Walker, R.F., Brooks, W.H., Markesbery, W.R.,
Roszman, T.L.: Neuroimmunomodulations: Influence of Serotonin on
the Immune Response. Immunology, 54:505-512, 1985.
Roszman, T.L., Jackson, J.C., Cross, R.J., Titus, M.J., Markesbery, W.R.,
Brooks, W.H..: Neuroanatomical and Neurotransmitter Influences
on Immune Function. Journal of Immunology 135:769-772, 1985.
Roszman, T.L., Brooks, W.H.: Neural Modulation of
Immune Function. Journal of Neuroimmunology 10:59-69, 1985.
Jackson, J.C., Cross, R.J., Walker,
R.J., Markesbery, W.R., Brooks, W.H., Roszman: Is Serotonin a
Modulator of the Immune Response? Proc. 1st International Workshop on
Neuroimmunomodulation 88-91, 1985.
Cross, R.J., Jackson, J.C., Markesbery, W.R., Brooks, W.H., Roszman, T.L.: Modulation of Immune Function by Electrolytic and Chemical Lesions of
the Central Nervous System. Proc. 1st International Workshop on
Neuroimmunomodulation 16-19, 1985.
Markesbery, W.R., Cross, R.J., Roszman, T.L., Brooks, W.H.: Aging Changes in Neuroimmunomodulation in the Fischer 344 Rat. proc.
1st International Workshop of Neuroimmunomoduation 23-26, 1985.
Cross, R.J., Jackson, J.C. Brooks, W.H., Sparks, D.L., Markesbery, W.R.,
Roszman, T.L.: Neuroimmunomodulation: Impairment of Immune
Responsiveness by 6-Hydroxdopamine Treatment. Immunology 57:145-152, 1986.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Activation
of Immunoregulatory Lymphocytes Obtained from Patients with Malignant Gliomas.
Journal of Neurosurgery 67:231-236, 1987.
Cross, R.J., Brooks, W.H., Roszman, T.L.: Modulation
of T-Suppresser Cell Activity by Central Nervous System Catecholamine Depletion.
Journal of Neuroscience Res. 18(1): 75-81, 1987.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Role of
Interleukin-2 and IL-2 Receptor Expression in the Proliferative Defect Observed in Mitogen
Stimulated Lymphocytes from Patients with Gliomas. Journal of National Cancer
Institute 75:919-922, 1987.
Cross, R.J., Brooks, W.H., Roszman,
T.L.: Neuroimmunomodulation Induction of Suppressor T-Cell
Activity by 6-Hydroxydopamine Treatment. Journal of Neuroscience Res.
Roszman, T.L., Brooks, W.H., Elliott, L.H.: Inhibition
of Lymphocyte Responsiveness by Glial Tumor Cell Derived Suppressive Factor.
Journal of Neurosurgery. 67:874-879, 1987
Roszman, T.L., Brooks, W.H.: In Vivo Interactions
Between the Immune and Neuroendocrine Systems - Bidirectional Communication.
Progress in Allergy 43:140-159, 1988.
Jackson, J.C., Walker, R.F., Brooks, W.H., Roszman, T.L.: Specific
Uptake of Serotonin by Murine Macrophages. Life Science 42:1641-1650, 1988.
Brooks, W.H., Hammett, D.B.: Prevention of Neurological Injuries in Equestrian Sports.
Phys. Sports Medicine 16:11-17, 1988.
Roszman, T.L., Brooks, W.H.: Signaling Pathways of
Neurotransmitter Immune Network. Invited Review in Neuroendocrine Immune
Network, Ed. S. Freier, CRC Press, Inc., 1989.
Carlson, S.L., Brooks, W.H., Roszman, T.L.: Neurotransmitter-Lymphocyte
Interactions: Dual Receptor Modulation of Lymphocyte Proliferation and Camp Production.
Journal of Neuroimmunology 24: 155-162, 1989.
Hammett, D.R., Brooks, W.H.: Common Injuries in
Horseback Riding: A Review. Sports Medicine 9(1): 36-47, 1990.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Inability
of Mitogen-Activated Lymphocytes Obtained from Patients with Malignant Primary
Intracranial Tumors to Express High Affinity Interleukin 2 Receptors. Journal
Clin-Invest. 86(1): 80-86, July, 1990.
Roszman, T.L., Brooks, W.H.: Signaling Pathways of
Neurotransmitter-Immune Network. In Neuroendocrine Immune Network, Ed. S.
Freier, CRC Press, Inc., PP 53-67, 1990.
Roszman, T.L., Elliott, L.H., Brooks, W.H.: Modulation
of T-Cell Function by Gliomas. Immunology Today, 12:370-374, 1991.
Roszman, T.L., Brooks, W.H.: Signaling Pathways of the
Neuroendocrine-Immune Network. Chem. Immunol. 52:170-190, 1992.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Suppression
of High Affinity IL-2 Receptors on Mitogen Activated Lymphocytes by Glioma-Derived
Suppressor Factor. J. Neuro-Oncology, 14: 1-7, 1992.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Inhibition
of Anti-CD3 Monoclonal Antibody Induced T-Cell Proliferation by Dexamethosone,
Isoproterenol, or Prostaglandin E2 Either Alone or in Combination. Cell, Mol. Neurobiol. 14: 1-7, 1992.
Bartik, M.M., Brooks, W.H., Roszman, T.L.: Modulation
of T-Cell Proliferation by Stimulation of the Beta Adrenergic Receptor: Lack of
Correlation Between Inhibition of T-Cell Proliferation and cAMP Accumulation.
Cell. Immunol. 148:408-412, 1993.
Elliott, L.H., Brooks, W.H., Roszman, T.L.: Inhibition
of Anti-CD3 Monoclonal Antibody Induced T-Cell Proliferation and II-2 Secretion by
Physiologic Combinations of Dexamethosone and Prostaglandin E2. Cell. Mol.
Neurobiol. 13:579-592, 1993.
Carlson, S.L., Trauth, K., Brooks, W.H., Roszman, T.L.: Enhancement
and Adaptation of Beta-Adrenergic-Induced cAMP Accumulation in T-Cells.
J.Cell. Physiol. 161: 39-48, 1994.
Bauman, G., Bartik, M., Brooks, W.H., Roszman, T.L.: Induction
of cAMP Dependent Protein Kinase A (PKA) Activity in T-Cells After Stimulation of the
Prostaglandin E2 and B-Adrenergic Receptors: Relationship Between PKA Activity and
Inhibition of Anti-CD3 Monoclonal Antibody Reduced T-Cell Proliferation. Cell.
Immunol. 158: 182-194, 1994.
Bartik, M.M., Bauman, G., Brooks, W.H., Roszman, T.L.: Costimulatory
Signals Modulate the Anti-Proliferative Effects of Agents that Elevate the cAMP in
T-Cells. Cell. Immunology. 158: 116-130, 1994.
Elliott, L.H., Brooks,W.H., Carlson, S.R., Moorford, L., Roszman, T.L.: T-Cell Receptor Mediated Tyrosine Phosphorylation of Proteins is Defective
in T-Cells Obtained from Patients with Gliomas. Submitted.
Selliah, N., Bartik, M.M., Carlson, S. L., Brooks, W.H., and Roszman, T.L.: Stimulation of the beta adrenergic receptoro on T-cells inhibits
anti-CD3 monoclonal anti-body-induced actin polymerization. J. Neuroimmunol.
56: 107-112, 1995.
BOOK CHAPTERS
Brooks, W.H., Mortara, R.H.: "Intracranial Neoplasms" in Current Diagnosis.
5th Edition H.F. Conn and R.B. Conn, Eds. Philadelphia: W.B. Saunders Co., 1977.
Brooks, W.H., Young, A.B.: "Prevention of Central
Nervous System Injury" in An Analysis and Evaluation of Modern Trends
Related to the Care and Prevention of Athletic Injuries. Bill Chambers, Ed.,
Claremont, California: N.C.C., Inc., 1977.
Brooks, W.H., Roszman, T.L.: "The Immunobiology
of Intracranial Tumors" in the Handbook of Cancer and Immunology. H
Waters, Ed., Garland Publishing Company, 1978.
Brooks, W.H., Roszman, T.L.: "Cellular Immune
Responsiveness of Patients with Primary Intracranial Tumors" in Brain
Tumors: Scientific Basis. Clinical Investigation and Current Therapy. D.G.T. Thomas
and D.I. Graham, Eds. Butterworth and Company Limited, London, England, 1980.
Butler, A.L., Brooks, W.H., Netsky, M.D.: "The
Classification and Biology of Brain Tumors" in Neurological Surgery.
Julian R. Youmans, Ed., Philadelphia: W.B. Saunders Co., 1981.
Roszman, T.L., Brooks, W.H.: "Neuroimmunology and
Aging" in Experimental and Clinical Investigation. R.L. Cooper,
R.F. Walker, Eds. Marcel-Dezkkar, N.E., N.Y., 1984.
Bixby-Hammett, D., Brooks, W.H.: "Injuries in
Horseback Riding: A Review" in Sports Medicine Digest 3:26-27,
1990.
Brooks, W.H. and Bixby-Hammett, D.: "Head and
Spinal Injuries Associated with Eqeustrian Sports: Mechanisms and Prevention" in
Athletic Injuries to the Head, Neck, and Face ED Jos & Torg - Mosby YR.
Book, 1991.
Brooks, W.H.: "Head and Neck Injury"
in The Female Athlete ED Ireland - Blackwell, in Press.
Bixby-Hammett, D.,and Brooks, W.H.: "Neurologic
Injuries in Equestrian Sport" in Sports Neurology. ED Jordan,
Tsairis, Warner, Aspen Publication, 1989.
Brooks, W.H. and Hammett, D.: "Mechanisms of
Accidents in Horseback Riding" in Sports Neurology. ED Jordan,
Tsairis, Warner, in Press.
Brooks, W.H. and T.L. Roszman. "The Reformation
of Biomechanical Research; Influence of the Market and Society" in Concepts
in Neurosurgery, Volume 9. James R. Bean, M.D., Ed., Williams & Wilkins,
Baltimore, Maryland, 1998.
ARTICLES
Selliah, N., M.M. Bartik, S.L.
Carlson, W.H. Brooks and T. L. Roszman. Stimulation of the beta
adrenergic receptor on T-cells inhibits anti-CD3 monoclonal antibody-induced actin
polymerization. J. Neuroimmunol. 56:107-112, 1995.
Selliah, N., W.H. Brooks and T. L. Roszman. Proteolytic
cleavage of a-actinin by calpain in T-cells stimulated with anti-CD3 monoclonal antibody.
J. Immunol. 156:3215-3221, 1996.
Morford, L.A., Boghaert, E.R., Brooks, W.H. and Roszman, T.L., Insulin-like growth factors (IGF) enhance three-dimensional (3D)
growth of human glioblastomas. Cancer Letters 115:81-90, 1997.
Elliott, L.H., Brooks, W.H., Carlson, S.R., Morford, L. and Roszman, T.L. T-cell receptor mediated signaling is defective in T-cells obtained from
patients with gliomas. J. Immunol. 159: 4415-4425, 1997.
Rock, M., W.H. Brooks and T. L. Roszman. Signaling of
T-cells induces activation of calpain and the subsequent proleoytic cleavage of PTP-1B
which binds to p130cas. J. Biol. Chem. 272:33377-33383, 1997.
Zou, Jian-Ping, Morford, Lorri A., Chougnet, Claire, Dix, Amy R., Brooks, Andrew
G., Torres, Naomi, Shuman, Jon D., Coligan, John E., Brooks, William H., Roszman, Thomas
L., and Shearer Gene M.: Human Glioma-Induced Immunosuppression
Involves Soluble Factor(s) That Alters Monocyte Cytokine Profile and Surface Markers.
The Journal of Immunology, 1999, 162: 4882-4892.
Brooks, W.H.: Results of a Multicenter Trial:
Intrathecal Lioresal (baclofen injection) for the Management of Spastic Cerebral Palsy.
Journal of Pediatric Neurosurgery. In Press, 1999.
Dix, Amy R., Brooks, W.H., Roszman, Thomas L., and Morford, Lorri A.: Immune Defects Observed in Patients with Primary Malignant Brain Tumors.
The Journal of Immunology. In Press, 1999.
RESEARCH
CITICOLINE STROKE STUDY - PROTOCOL #IP302-007. Institutional Principal
Investigator.
ALTEPLASE A0276q STUDY. Institutional Principal Investigator.
IMMUNOBIOLOGY 01(2) PRIMARY INTRACRANIAL TUMORS.
Co-Investigator.
NEUROIMMUNOMODULAITON. Co-Investigator.
SCHNEIDER CARTOID STENT VERSUS SURGERY CLINICAL TRIAL. Institutional
Principal Investigator.
CITICOLINE STROKE STUDY - PROTOCOL #IP302018.
Institutional Principal Investigator.
CAROTID ARTERY DISEASE OUTCOMES PILOT PROJECT II -
Principal Investigator.
GAIN AMERICA GLYCINE ANTAGONIST IN NEUROPROTECTION
- Principal Investigator.
"BEACH: BOSTON SCIENTIFIC/EPI - A CAROTID
STENTING TRIAL FOR HIGH RISK PATIENTS". - Principal Investigator.
CREST - Principal Investigator.
The MAVErIc Trial - Evaluation of the Medtronic AVE
self expanding carotid stent system with distal protection in the
treatment of carotid stenosis. - CO-Investigator.
A Prospective , Multi-Center, Long Term Follow up Study of Carotid
Artery Stenting in High Risk Patients Who Were Implanted With an
ACCULINK Stent in the ARCHeR Trial (ARCHer 1,2 and 3) ACCULINK for
Revascularization of Carotids in High Risk Patients "The ARCHeR Long
Term Follow-up (LTFU) Trial".
VIVEXX CAROTID REVASCULARIZATION TRIAL -
Principal Investigator. (VIVA - 2005)
MEDICAL LICENSURE
Kentucky
CERTIFICATION
American Board of Neurological Surgeons, 1976
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