William
H. Brooks, M.D.
EDUCATION
Pre-Med
University of Kentucky, 1965
M.D.
University of Kentucky, 1969
INTERNSHIP AND RESIDENCY
Intern, Surgery
1969 - 1970
New York University/Bellevue
New York, New York
Resident, Neurosurgery
1970 - 1971
University of Kentucky Medical Center
Lexington, Kentucky
Elective Residency, Neuropathology/Immunology
1971 - 1972
University of Virginia
Charlottesville, Virginia
Resident, Neurosurgery
1972 - 1974
University of Kentucky Medical Center
Lexington, Kentucky
MEDICAL LICENSURE
Kentucky
CERTIFICATION
American Board of Neurological Surgeons, 1976
APPOINTMENTS
Chief, Neurosurgery
Veterans Administration Hospital
Lexington, Kentucky
1974 - 1978
Assistant Professor
University of Kentucky Medical Center
Division of Neurosurgery
Lexington, Kentucky
1974 - 1978
Clinical Associate Professor
University of Kentucky Medical Center
Division of Neurosurgery/Experimental Pathology
Lexington, Kentucky
1978 - Present
HOSPITAL STAFF APPOINTMENTS
Central Baptist Hospital
Lexington, Kentucky
Saint Joseph Hospital
Lexington, Kentucky
Baptist Regional Medical Center
Corbin, Kentucky
MEDICAL SOCIETY MEMBERSHIPS
American Association of Neurological Surgeons
Congress of Neurological Surgeons
American Academy of Neurological & Orthopedic Surgeons
American Medical Association
American Medical Equestrian Association
Fayette County Medical Society
Kentucky Medical Association
Kentucky Neurological Society
Kentucky Surgical Society
National Stroke Society
Chairman - Neuroscience Center, Central Baptist Hospital.
2002 - Present
AWARDS AND HONORS
Fellowship - American Cancer Society
1973 - 1974
Recipient of Resident's Award
Southern Neurosurgical Society
For paper entitled, Immune Responses in Patients with Gliomas
1974
Teacher Investigator Award
NINCDS - not activated
1978
RESEARCH
Citicoline stroke study - Protocol #IP302-007 -
Institutional Principal Investigator.
Alteplase A0276q study -
Institutional Principal Investigator
Immunobiology 01(2) primary intracranial tumors -
Co-Investigator
Neuroimmunomodulation -
Co-Investigator
Schneider Carotid Stent vs. Surgery Clinical Trial -
Institutional Principal Investigator
Citicoline Stroke Study - PROTOCOL #IP302018 -
Institutional Principal Investigator
Carotid Artery Disease Outcomes Pilot Project II -
Principal Investigator
Gain America Glycine Antagonist in Neuroprotection -
Principal Investigator
Carotid Revascularization Endartercetomy vs. Stenting Trial (CREST) -
Principal Investigator
Prevention Regimen for Effectively Avoiding Second Strokes: PRoFESS -
Principal Investigator
VIVEXX - High surgical risk patients with extracranial carotid artery stenosis using the Bard VIVEXX™ carotid stent and emboshield bare wire rapid exchange embolic protection system -
Principal Investigator
SENTIS - Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke -
Principal Investigator
CAPTURE 2 - A post-approval study of the Guidant ACCULINK Stent Systems & ACCUNET Embolic Protection systems RX ACCULINK™ & RX ACCUNET™ post-approval trial to uncover unanticipated and rare events -
Principal Investigator
BEACH - Boston Scientific/EPI - A Carotid stenting trial for high risk patients -
Principal Investigator
The ARCHeR Trial - ACCULINK for revascularization of carotids in high risk patients: A prospective non-randomized, multi-center single-arm clinical trial to assess the safety and efficacy of the ACCULINK carotid stent system in the treatment of high-risk surgical patients and non-surgical patients with lesions in the internal carotid artery -
Principal Investigator
Albumin In Acute Stroke (ALIAS) Trial: Part 2 - A phase III randomized multi-center clinical trial of high-dose human albumin therapy for neuroprotection in acute ischemic stroke -
Principal Investigator
CHOICE - Carotid stenting for high surgical-risk patients; Evaluating outcomes through the collection of clinical evidence -
Principal Investigator
SAPPHIRE WW - Stenting and angioplasty with protection in patients at high-risk for endarterectomy -
Co-Investigator
The MAVErIc Phase III Trial - The Medtronic vascular self-expanding carotid stent system with distal protection in the treatment of carotid stenosis -
Co-Investigator
ACT I - Clinical trial asymptomatic carotid stenosis, stenting vs. endarterectomy trial -
Principal Investigator
PUBLICATIONS
Wheeler, D.D., Boyarsky, L.L., Brooks, W.H. -
The Release of Amino Acids from Nerve During Stimulation.
Journal of Cell Physiology, 67(1): 141, February 1966.
Walton, B.C., Benchoff, B.M. & Brooks, W.H. -
Comparison of the indirect fluorescent antibody test and methylene blue dye test for detection of antibodies to Toxoplasma gondii.
American Journal of tropical Medicine and Hygiene, 15(2): 149-152, March 1966.
Brooks, W.H., Netsky, M.G. & Horwitz, D.A. -
Evidence for Tumor Specific Immune Response in Patients with Primary Brain Tumors.
Surgery Forum, 23: 430-432, 1972.
Walton, B.C., Brooks, W.H. & Arjona, I. -
Serodiagnosis of American leishmaniasis by indirect fluorescent antibody test.
American Journal of Tropical Medicine and Hygiene, 12(3): 296-299, May 1972.
Brooks, W.H. -
Geographic Clustering of Brain Tumors in Kentucky.
Cancer, 30(4): 920-926, October 1972.
Brooks, W.H., Netsky, M.G., Normansell, D.E. & Horwitz, D.A. -
Depressed Cell-mediated Immunity in Patients with Primary Intracranial Tumors. Characterization of a humoral immunosuppressive factor.
Journal of Experimental Medicine 136(6): 296-299, December 1972.
Mortara, R.H., Parker, J.C. Jr. & Brooks, W.H. -
Glioblastoma Multiforme of the Spinal Cord.
Surgery Neurology 2(2): 115-119, March 1974.
Brooks, W.H., Mortara, R.H., Preston, D. -
The Clinical Limitations of brain scanning in metastatic disease.
Journal of Nuclear Medicine, 15(7): 620-621, July 1974.
Brooks, W.H., Caldwell, H., Mortara, R.H. -
Immune Response in Patients with Gliomas.
Surgical Neurology 2(6): 419-423, November 1974.
Mortara, R.H., Markesbery, W. & Brooks, W.H. -
Pontine Cyst Presenting as Trigeminal Pain - Case Report.
Journal of Neurosurgery 41(5): 636-639, November 1974.
Brooks, W.H., Netsky, M.G., Levine, J.E. -
Immunity and Tumors of Central Nervous System.
Surgical Neurology 3(4): 184-186, April 1975.
McCloskey, J.J., Parker, J.C., Brooks, W.H. & Blacker, H.M. -
Melanin as a Component of Cerebral Gliomas: the Melatonis Cerebral Ependymoma.
American Journal of Clinical Pathology 63: 759, May 1975.
Young, A.B., Brooks, W.H., Blacker, H.M. & Mortara, R.H. -
Microvascular Surgery for Stroke Prevention.
Journal of Kentucky Medical Association. 73(11): 599-601, November 1975.
Mortara, R.H., Sides, S.D. & Brooks, W.H. -
Removal of an Intracranial Glioblastoma in a Hemophiliac.
Surgical Neurology. 4(6): 505-507, December 1975.
Markesbery, W., Brooks, W.H., Milsow L. & Mortara, R.H. -
Ultrastructural Study of the Pineal Germinoma in Vivo and in Vitro.
Cancer 37(1): 327-337, January 1976.
Swick, H.M., Brooks, W.H., Roszman, T.L. & Caldwell, H.D. -
A Heat Stable Blocking Factor in the plasma of Patients with Subacute Sclerosing Panencephalitis.
Neurology 26(1): 84-88, January 1976.
Brooks, W.H., Roszman, T.L. & Rogers, A.S. -
Impairment of Rosette Forming T Lymphocytes in Patients with Primary Intracranial Tumors.
Cancer 37(4): 1869-1973, April 1976.
Mortara, R.H. & Brooks, W.H. -
Chronic Arachnoiditis after a Pantopaque Study of the Posterior Fossa.
Southern Medical Journal 69(4): 520-521. April, 1976.
McCloskey, J.J., Parker, J.C., Brooks, W.H. & Blacker, H.M. -
Melanin as a Component of Cerebral Gliomas: the Melatonis Cerebral Ependymoma.
Cancer, 37(5): 2373-2379, May 1976.
Brooks, W.H., Parker, J.C. Jr., Young, A.B. & Mortara, R.H. -
Malignant Gliomas of the Optic Chiasm in
Adolescents.
Clinical Pediatrics 15(6): 557-561, June 1976.
Brooks, W.H. & Young, A.B. -
High School Football Injuries: Prevention of injury to the central nervous system.
Southern Medical Journal 69(10): 1258-1260, October 1976.
Roszman, T.L., Brooks, W.H. & Muse, K.N. -
Effects of Preincubating Human Peripheral Blood Lymphocytes on their Ability to Bind Sheep Red Blood Cells.
Journal Immunological Methods 14(1): 93-100, January 1977.
Mahaley, M.S. J.r., Brooks, W.H., Roszman, T.L., Bigner, D.D., Dudka, L. & Richardson, S. -
Immunobiology of Primary Intracranial Tumors, Part I: Studies of the cellular and humoral general immune competence of brain tumor patients.
Journal of Neurosurgery 46(4): 467-476, April 1977.
Brooks, W.H., Mee, J.C. & Schimke, R.N. -
Gonadal Dysgenesis with Graves' Disease.
Journal of Medical Genetics 14(2): 128-129, April 1977.
Brooks, W.H., Roszman, T.L., Mahaley, M.S. & Woosley, R. -
Immunobiology of Primary Intracranial Tumors, Part II: Analysis of lymphocyte subpopulations in patients with primary brain tumors.
Clinical and Experimental Immunology 29(1): 61-66, July 1977.
Woosley, R.E., Mahaley, J.L., Miller, G.M. & Brooks, W.H. -
Immunobiology of Primary Intracranial Tumors, Part III: Microcytotoxicity assays of specific immune responses of brain tumor patients.
Journal of Neurosurgery 47(6): 871-885, December 1977.
Roszman, T.L., Brooks, W.H., Markesbery, W.R. & Bigner, D.D. :
General Immunocompetence of Rats Bearing Avian Sarcoma Virus Induced Intracranial Tumors.
Cancer Research 38(1): 74-77, January 1978.
Brooks, W.H., Markesbery, W.R., Gupta, G.D. & Roszman, T.L. :
Relationship of Lymphocyte Invasion and Survival of Brain Tumor Patients.
Annals of Neurology 4(3): 219-224, September 1978.
Young, A. B., Tibbs, P.A. & Brooks, W.H. :
Anterior Interbody Fusion for Unstable Thoracolumbar Fractures.
In Press - Journal of Neurosurgery - 1978.
Tibbs, P.A., Young, B., McAllister, R.G., Brooks, W.H. & Tackett, L. :
Studies of Experimental Cervical Spinal Cord Transection, Part I: Hemodynamic changes after acute cervical spinal cord transection.
Journal of Neurosurgery 49(4): 558-562, October 1978.
Markesbery, W.R., Brooks, W.H., Gupta, G.D. & Young, A.B. -
Treatment for Patients with Cerebral Metastases.
Archives of Neurology 35(11): 754-756, November 1978.
Tibbs, P.A. & Brooks, W.H. -
Traumatic bitemporal hemianopsia: case report.
The Journal of Trauma, 19(2): 129-131 February 1979.
Brooks, W.H. & Davidson, K.C. -
Thoracic Aortography. The evaluation of mediastinal masses.
Journal of the Kansas Medical Society 80(6): 327-331, June 1979.
Sims, W.L., Marx, M.B. & Brooks, W.H. -
A follow-up study of the geographic distribution of selected malignancies among Kentucky residents, 1969-1976.
Journal of National Medical Association 71(7): 685, July 1979.
Dixon, G.D., Brooks, W.H. & Kunz, S. -
Renal radiography with cephalad angulation and inspiration.
Radiology 133(1): 240-241, October 1979.
Young, B., Rapp, R., Brooks, W.H., Madauss, W. & Norton, J.A. -
Posttraumatic epilepsy prophylaxis.
Epilepsia 20(6): 671-681, December 1979.
Roszman, T.L. & Brooks, W.H. -
Immunobiology of primary intracranial tumours. III. Demonstration of a qualitative lymphocyte abnormality in patients with primary brain tumours.
Clinical Experimental Immunology 39(2): 395-402, February 1980.
Brooks, W.H., Mahaley, J.S. & Sheline, G.E. -
Adjunctive Therapy for Malignant Primary Brain Tumors.
Clinical Experimental Immunology 39(2): 395-402, February 1980.
Cross, R. J., Markesbery, W.R., Brooks, W.H. & Roszman, T.L. -
Hypothalamic-immune interactions. I. The acute effect of anterior hypothalamic lesions on the immune response.
Brain Research 196(1): 79-87, August 1980.
Brooks, W.H. & Dixon, G.D. -
A Simple aid in advancing Dobbhoff tubes.
Journal of Clinical Gastroenterology 2(30): 315, September 1980.
Walker, M.D., Green, S.B., Byar, D.P., Alexander, E., Batzdorf, V., Brooks, W.H., Hunt, W.E., MacCarty, C.S., Mahaley, M.S., Mealey, J., Owens, G., Ransohoff, J., Robertson, J.T., Sharpiro, W.R., Smith, K.R., Wilson, C.B. & Strike, T.A. -
Randomized Comparisons of Radiotherapy and Nitrosureas for the Treatment of Malignant Glioma After Surgery.
New England Journal of Medicine, 303(23): 1323-1329, December 1980.
Young, B., Brooks, W.H. & Tibbs, P.A. -
Anterior Decompression and Fusion for Thoracolumbar Fractures with Neurological Deficits.
Acta Neurochirurgica (Wien) 57(3-4): 287-298, 1981.
Brooks, W.H., Latta, R.B., Mahaley, M.D., Roszman, T.L., Dudka, L. & Skaggs, C. -
Immunobiology of Primary Intracranial Tumors. Part 5: Correlation of a lymphocyte index and clinical status.
Journal of Neurosurgery 54(3): 331-337, March 1981.
Spori, M., Sheil, J.M., Roszman, T.L. & Brooks, W.H. -
T-Lymphocyte Heterogeneity in Rat: role of adherent T-cell subpopulation in the regulation of cytotoxic T-cell response to alloantigens.
Cell Immunology 65(1): 103-114, November 15th 1981.
Cross, R.J., Roszman, T.L., Markesbery, W.R. & Brooks, W.H. -
Hypothalamic Immune Interactions, Part I: Effect of Hypophysectomy on Neuroimmunomodulation.
Journal of Neurological Science 53(3): 557-566, March 1982.
Roszman, T.L., Cross, R.J., Brooks, W.H. & Markesbery, W.R. -
Hypothalamic-immune interactions. II. The effect of hypothalamic lesions on the ability of adherent spleen cells to limit lymphocyte blastogenesis.
Immunology 45(4): 737-742, April 1982.
Roszman, T.L., Cross, R.J., Brooks, W.H. & Markesbery, W.R. -
Neuroimmunomodulation of Suppressor Cell Function.
Immunology 45: 731-742, 1982.
Brooks, W.H., Cross, R.J., Markesbery, W.R. & Roszman, T.L. -
Neuroimmunomodulation: Neural anatomical basis for impairment and facilitation.
Annals of Neurology 12(1): 56-61, July 1982.
Roszman, T.L., Brooks, W.H. & Elliott, L.H. -
Immunobiology of primary intracranial tumors. VI. Suppressor cell function and lectin-binding lymphocyte subpopulations in patients with cerebral tumors.
Cancer 50(7): 1273-1279, October 1982.
Green, S.B., Byar, D.P., Walker, M.D., Pistenma, D.A., Alexander, E., Ulrich, B., Brooks, W.H., Hunt, W.E., Mealey, Jr., Odom, G.L., Pietro, P., Ransohoff, J., Robertson, J.T., Selker, R.G., Shapiro, W.R., Smith, K.R., Wilson, C.B. & Strike, T.A. -
Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.
Cancer Treatment Reports 67(2): 121-132, February 1983.
Cross, R.J., Markesbery, W.R., Brooks, W.H. & Roszman, T.L. -
Neuromodulation of Lymphocyte Reactivity in Aged Rats.
Neurobiology of Aging 5(2): 89-92, 1984.
Cross, R.J., Markesbery, W.R., Brooks, W.H. & Roszman, T.L. -
Hypthalamic Immune Interactions: - Neuromodulation of the natural killer activity by lesioning of the anterior hypothalamus.
Immunology 51(2): 399-405, Febuary 1984.
Elliott, L.H., Brooks, W.H. & Roszman, T.L. -
Cytokinetic Basis for the Impaired Activation of Lympocytes from Patients with Primary Intracranial Tumors.
Journal of Immunology 132(3): 1208-1215, March 1984.
Cross, R.J., Jackson, J.J., Roszman, T.L., Brooks, W.H. & Markesbery, W.R. -
Role of Spontaneous Interstitial Cell Testicular Tumors on the Mitogen Reactivity of Spleen Cells from Aged male Fischer-344 Rats.
Mechanisms of Aging Development, 25(3): 349-353, June 1984.
Cross, R.J., Markesbery, W.R., Brooks, W.H. & Roszman, T.L. -
Neuromodulation of lymphocyte reactivity in aged rats.
Neurobiology of Aging, 5: 89-92, 1984.
Roszman, T. L., Brooks, W.H., Steele, C. & Elliott, L. H. -
Pokeweed Mitogen Induced Immunoglobulins Secretion of Peripheral Blood Lymphocytes from Patients with Primary Intracranial Tumors. Characterization of T-helper and B-cell Function.
Journal of Immunology, 134(3): 1545-1550, March 1985.
Jackson, J.C., Cross, R.H., Walker, R.F., Brooks, W.H., Markesbery, W.R. & Roszman, T.L. -
Influence of Serotonin on the Immune Response.
Immunology, 54(3): 505-512, March 1985.
Roszman, T., Jackson, J., Cross, R., Markesbery, W. & Brooks, W.H. :
Neuroanatomic and Neurotransmitter Influences on Immune Function.
Journal of Immunology, 135: 769s-772s, August 1985.
Cross, R.J., Jackson, J., Brooks, W.H., Sparks, D., Roszman, T. & Markesbery, W. -
Neuroimmunodulation: Impairment of Humoral Immune Responsiveness After Brain Catecholamine Depletion.
Immunology - In Press.
Roszman, T.L. & Brooks, W.H. -
Neural modulation of immune function.
Journal of Neuroimmunology, 10(1): 59-69, November 1985.
Cross, R.J., Jackson, J.C. Brooks, W.H., Sparks, D.L., Markesbery, W.R. & Roszman, T.L. -
Neuroimmunomodulation: Impairment of humoral Immune Responsiveness by 6-Hydroxydopamine Treatment.
Immunology, 57(1): 145-152, January 1986.
Cross, R.J., Brooks, W.H. & Roszman, T.L. -
Modulation of T-suppressor Cell Activity by Central Nervous System Catecholamine Depletion.
Journal of Neuroscience Research, 18(1): 75-81, March 1987.
Elliott, L.H., Brooks, W.H. & Roszman, T.L. -
Activation of Immunoregulatory Lymphocytes Obtained from Patients with Malignant Gliomas.
Journal of Neurosurgery, 67(2): 231-236, August 1987.
Elliott, L.H., Brooks, W.H. & Roszman, T.L. -
Role of Interleukin-2 (IL-2) and IL-2 Receptor Expression in the Proliferative Defect Observed in Mitogen Stimulated Lymphocytes from Patients with Gliomas.
Journal of National Cancer Institute, 75: 919-922, 1987.
Roszman, T.L., Brooks, W.H. & Elliott, L.H. -
Inhibition of Lymphocyte Responsiveness by Glial Tumor Cell-derived Suppressive Factor.
Journal of Neurosurgery, 67(6): 874-879, December 1987.
Roszman, T.L. & Brooks, W.H. -
In Vivo Interactions Between the Immune and Neuroendocrine Systems - Bidirectional Communication.
Progress in Allergy, 43: 140-159, 1988.
Jackson, J.C., Walker, R.F., Brooks, W.H. & Roszman, T.L. -
Specific Uptake of Serotonin by Murine Macrophages.
Life Science, 42(17): 1641-1650, 1988.
Brooks, W.H. & Hammett, D.B. -
Prevention of Neurological Injuries in Equestrian Sports.
Physical Sports Medicine, 16: 11-17, 1988.
Roszman, T.L., Brooks, W.H. -
Signaling Pathways of Neuroendocrine Immune Network.
Progression in Allergy, 43: 140-159, 1988.
Carlson, S.L., Brooks, W.H. & Roszman, T.L. -
Neurotransmitter-Lymphocyte Interactions: Dual Receptor Modulation of Lymphocyte Proliferation and cAMP Production.
Journal of Neuroimmunology, 24(1-2): 155-162, September 1989.
Bixby-Hammett, D. & Brooks, W.H. -
Common Injuries in Horseback Riding: A Review.
Sports Medicine, 9(1): 36-47, January 1990.
Elliott, L.H., Brooks, W.H. & Roszman, T.L. -
Inability of Mitogen-Activated Lymphocytes Obtained from Patients with Malignant Primary Intracranial Tumors to Express High Affinity Interleukin 2 Receptors.
Journal of Clinical Investigation, 86(1): 80-86, July 1990.
Roszman, T.L., Elliott, L.H. & Brooks, W.H. -
Modulation of T-Cell Function by Gliomas.
Immunology Today, 12: 370-374, 1991.
Roszman, T.L. & Brooks, W.H. -
Signaling Pathways of Neuroendocrine Immune Network.
Chemical Immunology, 52: 170-190, 1992
Elliott, L.H., Brooks, W.H., Roszman, T.L. -
Suppression of High Affinity IL-2 Receptors on Mitogen Activated Lymphocytes by Glioma-Derived Suppressor Factor.
Journal of Neuro-Oncology, 14(1): 1-7, September 1992.
Elliott, L.H., Brooks, W.H. & Roszman, T.L. -
Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation by dexamethasone, isoproterenol, or prostaglandin E2 either alone or in combination.
Cellular & Molecular Neurobiology, 12(5): 411-427, October 1992.
Roszman T.L., Elliott L.H. & Brooks W.H. -
Proliferative potential of T-cell lymphocytes from gliomas.
Journal of Neurosurgery, 77(5): 820-821, November 1992.
Bartik, M.M., Brooks, W.H., Roszman, T.L. -
Modulation of T-Cell Proliferation by Stimulation of the Beta Adrenergic Receptor: Lack of Correlation Between Inhibition of T-Cell Proliferation and cAMP Accumulation.
Cellular Immunology, 148(2): 408-412, May 1993.
Elliott, L.H., Brooks, W.H., Roszman, T.L. -
Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation and interleukin-2 secretion by physiologic combinations of dexamethasone and prostaglandin E2.
Cellular & Molecular Neurobiology, 13(6): 579-592, December 1993.
Carlson, S.L., Trauth, K., Brooks, W.H. & Roszman, T.L. -
Enhancement of beta-adrenergic-induced cAMP accumulation in activated T-cells.
Journal of Cellular Physiology, 161(1): 39-48, October 1994.
Bauman, G.P., Bartik, M.M., Brooks, W.H. & Roszman, T.L. -
Induction of cAMP-dependent protein kinase (PKA) activity in T cells after stimulation of the prostaglandin E2 or the beta-adrenergic receptors: relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation.
Cellular Immunology, 158(1): 182-194, October 1994.
Bartik, M.M., Bauman, G., Brooks, W.H., Roszman, T.L. -
Costimulatory signals modulate the antiproliferative effects of agents that elevate cAMP in T Cells.
Cellular Immunology, 158(1): 116-130, October 1994.
Selliah, N., Bartik, M.M., Carlson, S. L., Brooks, W.H. & Roszman, T.L. -
cAMP accumulation in T-cells inhibits anti-CD3 monoclonal antibody-induced actin polymerization.
Journal of Neuroimmunology, 56(1): 107-112, January 1995.
Selliah N., Brooks W.H. & Roszman T.L. -
Proteolytic cleavage of alpha-actinin by calpain in T cells stimulated with anti-CD3 monoclonal antibody.
Journal of Immunology, 156(9): 3215-3221, May 1996
Roszman T.L. & Brooks W.H. -
Interactive signaling pathways of the neuroendocrine-immune network.
Chemical Immunology, 69: 203-222, 1997.
Morford L.A., Boghaert E.R., Brooks W.H., & Roszman T.L. -
Insulin-like growth factors (IGF) enhance three-dimensional (3D) growth of human glioblastomas.
Cancer Letters, 115(1): 81-90, May 1997
Elliott, L.H., Brooks,W.H., Carlson, S.R., Moorford, L.A. & Roszman, T.L. -
T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors.
Journal of Immunology, 159(9): 4415-4425, November 1997.
Rock M.T., Brooks W.H. & Roszman T.L. -
Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events.
Journal of Biological Chemisty 272(52): 33377-33383, December 1997.
Zou J.P., Morford L.A., Chougnet C., Dix A.R., Brooks A.G., Torres N., Shuman J.D., Coligan J.E., Brooks W.H., Roszman T.L. & Shearer G.M. -
Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers.
Journal of Immunology, 162(8): 4882-4892, April 1999.
Morford L.A., Dix A.R., Brooks W.H. & Roszman T.L. -
Apoptotic elimination of peripheral T lymphocytes in patients with primary intracranial tumors.
Journal of Neurosurgery, 91(6): 935-946, December 1999.
Dix A.R., Brooks W.H., Roszman T.L. & Morford L.A. -
Immune defects observed in patients with primary malignant brain tumors.
Journal of Neuroimmunology, 100(1-2): 216-232, December 1999.
Gilmartin R., Bruce D., Storrs B.B., Abbott R., Krach L., Ward J., Bloom K., Brooks W.H., Johnson D.L., Madsen J.R., McLaughlin J.F. & Nadell J. -
Results of a Multicenter Trial: Intrathecal Lioresal (baclofen injection) for the Management of Spastic Cerebral Palsy.
Journal of Child Neurology, 15(2): 71-77, February 2000.
Rock M.T., Dix A.R., Brooks W.H. & Roszman T.L. -
Beta1 integrin-mediated T cell adhesion and cell spreading are regulated by calpain.
Experimental Cell Research, 261(1): 260-270, November 2000.
Brooks W.H., McClure R.R., Jones M.R., Coleman T.C., Breathitt L. -
Carotid angioplasty and stenting versus carotid endarterectomy: randomized trial in a community hospital.
Journal of the American College of Cardiology, 38(6): 1589-1595, November 2001.
Morford L.A., Forrest K., Logan B., Overstreet L.K., Goebel J., Brooks W.H., Roszman T.L. -
Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells.
Cytogenetic and Genome Research, 97(1-2): 28-31, July 2002.
Hood J.L., Logan B.B., Sinai A.P., Brooks W.H. & Roszman T.L. -
Association of the calpain/calpastatin network with subcellular organelles.
Biochemical and biophysical research communications, 310(4): 1200-12, October 2003.
Brooks W.H., McClure R.R., Jones M.R., Coleman T.L. & Breathitt L. -
Carotid angioplasty and stenting versus carotid endarterectomy for treatment of asymptomatic carotid stenosis: a randomized trial in a community hospital.
Neurosurgery, 54(2): 318-325, February 2004.
Krach L.E., Kriel R.L., Gilmartin R.C., Swift D.M., Storrs B.B., Abbott R., Ward J.D., Bloom K.K., Brooks W.H., Madsen J.R., McLaughlin J.F. & Nadell J.M. -
Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion.
Pediatric Neurology, 30(3): 163-168, March 2004.
Hood J.L., Brooks W.H. & Roszman T.L.
Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.
The Journal of Biological Chemistry, 279(41): 43126-43135, October 2004.
Krach L.E., Kriel R.L., Gilmartin R.C., Swift D.M., Storrs B.B., Abbott R., Ward J.D., Bloom K.K., Brooks W.H., Madsen J.R., McLaughlin J.F., Nadell J.M. -
GMFM 1 year after continuous intrathecal baclofen infusion.
Pediatric Rehabilitation, 8(3): 207-13, July - September 2005.
Hood J.L., Brooks W.H. & Roszman T.L.
Subcellular mobility of the calpain/calpastatin network: an organelle transient.
Bioessays, 28(8): 850-859, August 2006
Jones M.R. & Brooks W.H. -
Acute cerebral rescue during carotid artery stenting: a stroke of good fortune?
Catheterization and Cardiovascular Interventions, 73(6): 749-752, May 2009.
BOOK CHAPTERS
Brooks, W.H. & Mortara, R.H. -
"Intracranial Neoplasms"
in Current Diagnosis. 5th Edition H.F. Conn and R.B. Conn, Eds. Philadelphia: W.B. Saunders Co., 1977.
Brooks, W.H. & Young, A.B. -
"Prevention of Central Nervous System Injury"
in An Analysis and Evaluation of Modern Trends Related to the Care and Prevention of Athletic Injuries.
Bill Chambers, Ed., Claremont, California: N.C.C., Inc., 1977.
Brooks, W.H. & Roszman, T.L. -
"The Immunobiology of Intracranial Tumors"
in the Handbook of Cancer and Immunology.
H Waters, Ed., Garland Publishing Company, 1978.
Brooks, W.H. & Roszman, T.L. -
"Cellular Immune Responsiveness of Patients with Primary Intracranial Tumors"
in Brain Tumors: Scientific Basis. Clinical Investigation and Current Therapy.
D.G.T. Thomas and D.I. Graham, Eds. Butterworth and Company Limited, London, England, 1980.
Butler, A.L., Brooks, W.H. & Netsky, M.D. -
"The Classification and Biology of Brain Tumors"
in Neurological Surgery.
Julian R. Youmans, Ed., Philadelphia: W.B. Saunders Co., 1981.
Roszman, T.L. & Brooks, W.H. -
"Neuroimmunology and Aging"
in Experimental and Clinical Investigation.
R.L. Cooper, R.F. Walker, Eds. Marcel-Dezkkar, N.E., N.Y., 1984.
Bixby-Hammett, D. & Brooks, W.H. -
"Injuries in Horseback Riding: A Review"
in Sports Medicine Digest
3:26-27, 1990.
Brooks, W.H. & Bixby-Hammett, D. -
"Head and Spinal Injuries Associated with Equestrian Sports: Mechanisms and Prevention"
in Athletic Injuries to the Head, Neck, and Face
ED Jos & Torg - Mosby YR. Book, 1991.
Brooks, W.H. -
"Head and Neck Injury"
in The Female Athlete ED Ireland - Blackwell, in Press.
Bixby-Hammett, D. & Brooks, W.H. -
" Neurologic Injuries in Equestrian Sport"
in Sports Neurology.
ED Jordan, Tsairis, Warner, Aspen Publication, 1989.
Brooks, W.H. & Hammett, D. -
"Mechanisms of Accidents in Horseback Riding"
in Sports Neurology
ED Jordan, Tsairis, Warner, in Press.
Brooks, W.H. & Roszman, T.L. -
"The Reformation of Biomechanical Research; Influence of the Market and Society"
in Concepts in Neurosurgery, Volume 9.
James R. Bean, M.D., Ed., Williams & Wilkins, Baltimore, Maryland, 1998.
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